Acute cellular and molecular cardiac effects of endurance exercise
The prevalence of heart failure in the western world is estimated to be 1-2% and is expected to rise as a consequence of improved survival of other cardiac diseases and the aging population. The morbidity and mortality of patients with heart failure are high and the costs of treatment and follow-up of this group of patients are substantial. Many previous studies have documented the beneficial effects of chronic endurance exercise and aerobic interval training as part of the treatment and rehabilitation of patients with heart failure.
The aim of the preset study is to examine the molecular changes that occur in heart muscle cells immediately after a bout of aerobic interval exercise and to investigate how these changes could be used as new potential therapeutic targets for future heart failure treatment.
We will utilize a well-established animal model of heart failure in rats. A total of 132 rats will be included in the study. Rats in the heart failure groups will undergo myocardial infarction surgery to induce heart failure. The rats will then be given one week to familiarize with the treadmill prior to a bout of aerob interval exercise. Finally, there will be conducted molecular analysis on isolated cardiac tissue.
In order to study the molecular effects of exercise in heart failure it is necessary to use an animal model. The animal model that will be used in this study is well-known and the research group have long experience with both the heart failure model and exercise training in animal models. The number of animals included in the study is set to a minimum of what is needed based on statistical analysis.
The aim of the preset study is to examine the molecular changes that occur in heart muscle cells immediately after a bout of aerobic interval exercise and to investigate how these changes could be used as new potential therapeutic targets for future heart failure treatment.
We will utilize a well-established animal model of heart failure in rats. A total of 132 rats will be included in the study. Rats in the heart failure groups will undergo myocardial infarction surgery to induce heart failure. The rats will then be given one week to familiarize with the treadmill prior to a bout of aerob interval exercise. Finally, there will be conducted molecular analysis on isolated cardiac tissue.
In order to study the molecular effects of exercise in heart failure it is necessary to use an animal model. The animal model that will be used in this study is well-known and the research group have long experience with both the heart failure model and exercise training in animal models. The number of animals included in the study is set to a minimum of what is needed based on statistical analysis.