Test the efficacy of compounds v,w and x against pathogen L in Atlantic salmon
Begrunnelse for etterevalueringen
Forsøket er betydelig belastende.
Etterevaluering
Overall the objectives set forth in application were realized. The trials have helped identify the efficacy and pharmacokinetic profile of 3 compounds v, w and x
Overall severity at the end of the application period is moderate which is below the severity level stated in the application. The overall number of fish used in the study is also less due to 1 study mentioned in the application not being conducted.
The testing on live animals could not be replaced in this type of trial. Reduction was achieved by using minimal number of fish to generate descriptive statistical data sufficient to compare the efficacy of 3 compounds v, w and x. Refinement was achieved by optimizing the lice use to infest the fish thereby reducing the severity level to moderate.
Overall severity at the end of the application period is moderate which is below the severity level stated in the application. The overall number of fish used in the study is also less due to 1 study mentioned in the application not being conducted.
The testing on live animals could not be replaced in this type of trial. Reduction was achieved by using minimal number of fish to generate descriptive statistical data sufficient to compare the efficacy of 3 compounds v, w and x. Refinement was achieved by optimizing the lice use to infest the fish thereby reducing the severity level to moderate.