The effect of hyperoxia on patient derived xenograft breast cancer models
Breast cancer is the most common cancer and the leading cause of cancer death in female’s worldwide. The majority of breast cancer related mortality (90%) is attributed to distal tumor metastasis. Metastasis is a complex process which involves detachment of cancer cells, penetration into the circulation and lymph and migration to distal determined sites which in breast cancer are mainly lungs, bone, liver and brain.
We have previously shown that hyperoxia attenuated or markedly reduced breast cancer growth using different tumor models such as chemically induced (DMBA), murine (4T1) and human (MDA-MB-231, and BT-474). We have newly published an article showing that hyperoxia significantly reduces the number and area of metastasis in a human breast cancer model. To be able to be even more clinically relevant we need to verify these significant results in patient derived xenograft (PDX) models as well.
We have previously shown that hyperoxia attenuated or markedly reduced breast cancer growth using different tumor models such as chemically induced (DMBA), murine (4T1) and human (MDA-MB-231, and BT-474). We have newly published an article showing that hyperoxia significantly reduces the number and area of metastasis in a human breast cancer model. To be able to be even more clinically relevant we need to verify these significant results in patient derived xenograft (PDX) models as well.