HER2 therapy in endometrial cancer
Endometrial cancer is a common cancer form in the Western world, particularly among women with advancing age. Prognosis is poor in patients with aggressive disease, and thus there is a constant search for more efficient treatment strategies.
An aggressive tumor is frequently associated with having a high expression of epidermal growth factor receptor 2 (HER2). Furthermore, a low expression of the transcription factor forkhead box protein A1 (FOXA1) has been associated with unfavorable effects on survival.
Thus, the aim of the current application is to test the hypothesis that therapeutic effect in tumors with highly expressed HER2 may additionally be depending on the expression of FOXA1. This will be performed by using a cell-line based, as well as a patient-derived xenograft (PDX) Nod/Scid mouse model, with a total of 99 animals. A comparison of the cell-line based model to the PDX model will enable us to make better decisions on optimal models in future experiments. The mice will be monitored closely for signs of progressive disease, and will also be evaluated by using novel non-invasive imaging techniques, providing an ideal tool for establishing the humane endpoint.
An aggressive tumor is frequently associated with having a high expression of epidermal growth factor receptor 2 (HER2). Furthermore, a low expression of the transcription factor forkhead box protein A1 (FOXA1) has been associated with unfavorable effects on survival.
Thus, the aim of the current application is to test the hypothesis that therapeutic effect in tumors with highly expressed HER2 may additionally be depending on the expression of FOXA1. This will be performed by using a cell-line based, as well as a patient-derived xenograft (PDX) Nod/Scid mouse model, with a total of 99 animals. A comparison of the cell-line based model to the PDX model will enable us to make better decisions on optimal models in future experiments. The mice will be monitored closely for signs of progressive disease, and will also be evaluated by using novel non-invasive imaging techniques, providing an ideal tool for establishing the humane endpoint.