ABC transporter role and function in Multiple Sclerosis (MS)
The aim of this project is to evaluate the role and function of ABC transporter subtypes in general and cell type-specifically for the pathogenesis and progression of Multiple Sclerosis (MS).
Our research will provide valuable new insights into the pathogenesis of MS and uncover novel starting points for the development of targeted MS therapy which can be more effective in regulating disease while producing less side effects for the patients.
The experiments will be performed in mice and phased in such a timely and logical manner that the minimal number of research animals will be used to obtain robust results. Thus, only research paths which yield statistically significant and clinically relevant results in first trials will be further pursued.
The development and progression of MS involves a complex interplay of different cell types in different 3-dimensional tissue-specific arrangements. To date, there are no in vitro models that can effectively recapitulate these complex settings to deliver reliable results. Furthermore, in order to clearly identify immune processes and starting points for therapy in MS, which can lead to the advancement of drugs for clinical studies in humans, animal models are an inevitable mean for testing to exclude severe adverse side effects.
Our research will provide valuable new insights into the pathogenesis of MS and uncover novel starting points for the development of targeted MS therapy which can be more effective in regulating disease while producing less side effects for the patients.
The experiments will be performed in mice and phased in such a timely and logical manner that the minimal number of research animals will be used to obtain robust results. Thus, only research paths which yield statistically significant and clinically relevant results in first trials will be further pursued.
The development and progression of MS involves a complex interplay of different cell types in different 3-dimensional tissue-specific arrangements. To date, there are no in vitro models that can effectively recapitulate these complex settings to deliver reliable results. Furthermore, in order to clearly identify immune processes and starting points for therapy in MS, which can lead to the advancement of drugs for clinical studies in humans, animal models are an inevitable mean for testing to exclude severe adverse side effects.