Breeding of the INS-GAS strain
Purpose: Keeping INS-GAS transgenic mouse strain
Expected distress for the animals: moderate
Expected scientific or societal benefit: Spontaneous gastric inflammation and tumorigenesis that mimic gastric cancer in humans.
How many and what kind of animals to be used: 100 INS-GAS mice
How demands for replacement, reduction and improvement will be adhered to: utilize this model to develop tumor spheroid/organoid lines for replacement, reduction and improvement purposes in the future
Expected distress for the animals: moderate
Expected scientific or societal benefit: Spontaneous gastric inflammation and tumorigenesis that mimic gastric cancer in humans.
How many and what kind of animals to be used: 100 INS-GAS mice
How demands for replacement, reduction and improvement will be adhered to: utilize this model to develop tumor spheroid/organoid lines for replacement, reduction and improvement purposes in the future