Testing of a "strokefinder" on sheep
The objectives of this trial is to establish a biomedical sheep model for testing of a so called "stroke finder" based on microwave technology. The preliminary trials of this equipment has shown the potential of detecting compromized blood supply to the brain due to thrombosis. The existing product has to be tested on animals before going into clinical human trials. The time to market is expected to be short thereafter. Stroke triage is the evaluation and decision making process that occurs when health care personnel arrives at the scene of a suspected stroke. The goal of the project is to provide a tool that supports that decision making process. If a thrombosis is detected the human patient needs to be transported to a designated thrombectomy-capable stroke center. Depending on the distance this might be by ambulance or ambulance helicopter. If there is no thromboses detected transportation to the nearest stroke center might be advisable making the scarce resources of interventionalists and ambulance helicopters available for more needing patients. The ultimate objective is to reduce the risk for death and provide optimal care of the patients.
This is a trial during which the sheep will be anaesthetized adequately and monitored continuously. The ewes vital signs including systolic and diastolic blood pressure, heart rate, SpO2 and core body temperature will be monitored continiously during surgery. Insignificant adverse effects are expected since quality assured protocols for anaesthesia in sheep will be applied and because any signs of discomfort or pain (by changes in vital signs) can be corrected for immediately. A thrombosis will be mimicked by inflating a balloon in the external carotid artery. Contrast agents and CT-scans will be used to verify if the model is functioning as expected. The animals will be euthanized while still anaesthetized.
The benefits from the equipment assessment in a biomedical sheep model are great. The equipment called stroke finder has the potential is to contribute to a development where more human patients are treated with thrombectomy than are treated today.
The project has the potential is to contribute to a development where more patients are treated with thrombectomy than are treated today and thereby increase the probability of recovery of such patients. This can increase the quality of life and also the costs for society by reducing the expences for rehabilitation of patients.
We will test the technology on up to ten Norwegian white sheep (NKS) ewes aged one year or more. This technology has so far been tested on trauma patients
The animals will be monitored closely an the depth of anaesthesia and analgesia will be adjusted continuously according to the procedures. Animal testing of the technology is an essential step for quality assurance before the commercialization of the stroke finder can be completed.
This is a trial during which the sheep will be anaesthetized adequately and monitored continuously. The ewes vital signs including systolic and diastolic blood pressure, heart rate, SpO2 and core body temperature will be monitored continiously during surgery. Insignificant adverse effects are expected since quality assured protocols for anaesthesia in sheep will be applied and because any signs of discomfort or pain (by changes in vital signs) can be corrected for immediately. A thrombosis will be mimicked by inflating a balloon in the external carotid artery. Contrast agents and CT-scans will be used to verify if the model is functioning as expected. The animals will be euthanized while still anaesthetized.
The benefits from the equipment assessment in a biomedical sheep model are great. The equipment called stroke finder has the potential is to contribute to a development where more human patients are treated with thrombectomy than are treated today.
The project has the potential is to contribute to a development where more patients are treated with thrombectomy than are treated today and thereby increase the probability of recovery of such patients. This can increase the quality of life and also the costs for society by reducing the expences for rehabilitation of patients.
We will test the technology on up to ten Norwegian white sheep (NKS) ewes aged one year or more. This technology has so far been tested on trauma patients
The animals will be monitored closely an the depth of anaesthesia and analgesia will be adjusted continuously according to the procedures. Animal testing of the technology is an essential step for quality assurance before the commercialization of the stroke finder can be completed.