Seafood - meat ratio in obesity

The aim of this study is to determine the effect of the dietary seafood:meat ratio on obesity development and glucose tolerance. The effects from intake of western diets with a varying meat:seafood ratio will be evaluated in C57BL/6J mice. The results from this study will be used to determine a potential beneficial effect of reducing the dietary meat:seafood ratio, in relation to obesity development and modulated glucose tolerance. The impact on obesity from different dietary ratios with meat and seafood is unknown, but more knowledge about this can help to understand factors important for preventing and/or inducing obesity, in addition to detect important mechanisms that are involved and modulate the whole body metabolism. 80 male C57BL/6J mice will be used, as a whole organism is necessary to include the impact from the whole body metabolism that is involved in diet induced obesity development and glucose metabolism. All animal handling will be performed by experienced staff, and care is taken to minimize stress imposed on the animals. No invasive procedures are planned during the experiment. The experimental set-up is performed in order to minimize the stress of the animals and reduce animals to lowest possible number.