Preclinical evaluation of macrophage-specific CAR T cell immunotherapy
Dette vil ikke medføre endringer i forsøkssammendraget:
- Purpose: To assess efficacy and safety of macrophage-specific CAR T cell immunotherapy against solid tumors and optimize treatment conditions for minimization of side effects.
- Expected injury: S.c. tumors cause minimal discomfort. T cell therapy generally causes transient and reversible weight-loss.
- Benefit: Experiments will facilitate optimisation of T-cell immunotherapy, allowing increased efficacy and minimisation of side-effects. If successful, our treatment regimen offers a radically new treatment strategy for management of solid tumors. This may have great impact on cancer management. Experiments are designed to allow in-depth understanding of the factors required for successful clinical implementation, and pave the way for clinical evaluation.
- Experiment size: The experimental setup involves the use of a total of 1600 inbred mus musculus, details of the various strains are further specified in the designated section of the application.
- 3R complicance: Group sizes are kept at a minimum required for statistically firm conclusions. Use of bioluminescence and extensive ex vivo studies yields a lot of information from each experiment and greatly limits the number of animals needed.
- Purpose: To assess efficacy and safety of macrophage-specific CAR T cell immunotherapy against solid tumors and optimize treatment conditions for minimization of side effects.
- Expected injury: S.c. tumors cause minimal discomfort. T cell therapy generally causes transient and reversible weight-loss.
- Benefit: Experiments will facilitate optimisation of T-cell immunotherapy, allowing increased efficacy and minimisation of side-effects. If successful, our treatment regimen offers a radically new treatment strategy for management of solid tumors. This may have great impact on cancer management. Experiments are designed to allow in-depth understanding of the factors required for successful clinical implementation, and pave the way for clinical evaluation.
- Experiment size: The experimental setup involves the use of a total of 1600 inbred mus musculus, details of the various strains are further specified in the designated section of the application.
- 3R complicance: Group sizes are kept at a minimum required for statistically firm conclusions. Use of bioluminescence and extensive ex vivo studies yields a lot of information from each experiment and greatly limits the number of animals needed.